FUS and amyotrophic lateral sclerosis: Deregulation of circRNAs and not of their linear counterparts, has also been reported in in vitro derived motor neurons lacking the FUS gene or carrying FUS mutations linked to a severe form of familial ALS (Errichelli et al., 2017; D’Ambra et al., 2019), suggesting a possible role of circRNAs in the pathogenesis of this disorder.