CREB1 and Parkinson disease: Feng et al. (2019) demonstrated that circDLGAP4 participates in PD biological processes regulating miR-134-5p activity. The reduction of CircDLGAP4 expression in PD conditions allows miR-134-5p to repress CREB1 and, as a consequence, the CREB1 target genes including BDNF, Bcl-2 and PGC-1. This would contribute to the development of PD via affecting cell viability, apoptosis, mitochondrial damage and autophagy in human and mouse (Feng et al., 2019).