HGF and neoplasm: Bendinelli et al. (2017) indicated the importance of targeting the tumor microenvironment by blocking epigenetic mechanisms that control critical events for colonization, such as the HGF/Met axis and WW domain-containing oxidoreductase, as a therapy for bone metastasis. The deregulation of HGF/MET signaling in tumors, including overexpression, gene amplification, activation of mutations, and increased autocrine or paracrine ligand-mediated stimulation, is caused by many different mechanisms (Migliore and Giordano, 2008).