TNFRSF18 and acute myeloid leukemia: Other checkpoint pathways of interest in AML include T cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT), T cell immunoglobulin domain and mucin domain 3 (TIM-3), and glucocorticoid induced tumor necrosis factor receptor related protein (GITR) (120–122).