Moreover, positive Cbl-b expression indicated favorable prognosis in terms of DFS for patients with HR-positive/HER2-positive, age > 35 years, histological grade 2–3, tumor size > 2 cm, lymph node metastasis, stage II–III and premenopausal breast cancer (Figure 3B). The gene discussed is ERBB2; the disease is metastatic malignant neoplasm in the lymph nodes.