EZH2 was intimately involved in platinum resistance according to previous studies: EZH2 was overexpressed in cancer stem-like cells enriched by platinum (Wen et al., 2017); EZH2-H3K27Me3 axis induced chromatin condensation, SLFN11 gene silencing, DNA-damage repair deficiency and acquired platinum resistance (Gardner et al., 2017). The gene discussed is EZH2; the disease is cancer.