The aims of this study were (i) the identification of circulating lncRNAs as candidate markers for the detection of malignant mesothelioma using previously published RNA expression profiles from Gene Expression Omnibus (GEO), (ii) the verification using mesothelioma cell lines as well as human plasma samples from mesothelioma patients and subjects formerly exposed to asbestos as controls, and (iii) to assess the possible benefit of adding new candidate markers to the established marker panel of calretinin and mesothelin for the detection of malignant mesothelioma in liquid biopsies. Here, CALB2 is linked to malignant mesothelioma.