Such divergent results were also obtained for the lncRNA MALAT1, reflecting that in spite of its ubiquitous expression MALAT1 could function in a cell type- or tissue-specific manner [26], and the same might be true for GAS5. Accordingly, despite the described predominant role as tumor suppressor, it appears that GAS5 might also act as an oncogene, not only in mesothelioma but also in other malignancies, e.g. prostate and esophageal cancer [27, 28]. The gene discussed is GAS5; the disease is esophageal cancer.