TNFSF10 and neoplasm: pDCs also elicit anti-tumor responses by their ability to induce antigen-specific adaptive responses (14, 15) or by exerting a direct cytotoxic activity toward the tumor cells via TRAIL (16, 17), but are found to be subverted in many cancers and to contribute to the establishment of an immunosuppressive tumor microenvironment (18, 19).