SOX9 and myocardial infarction: Another recent study combining TOMO-seq and transcription factor binding site analysis identified SOX9 as a potential novel transcription factor activating the expression of fibrotic genes in the heart (Lacraz et al., 2017), which might explain the amelioration in MI-induced cardiac dysfunction, fibrosis, and dilation in mice with cardiac fibroblast-specific deletion of Sox9 (Scharf et al., 2019).