A study found that in angiotensin II (Ang II) infusion-induced cardiomyopathy, the myofibroblast-specific deletion of Rock2 significantly reduced αSMA expression in these cells, together with reduced connective tissue growth factor (CTGF) and FGF2 expression in cardiac fibroblasts, and improved cardiac function and fibrosis (Shimizu et al., 2017). The gene discussed is CCN2; the disease is cardiomyopathy.