CXCL8 and melanoma: For example, MEK-1/2 inhibitor PD184352 decreased PGE2 production in melanoma cell line by decreased COX-2 expression due to inhibition of phosphorylation on ERK (Zelenay et al., 2015) and trametinib reduced IL-8 production in melanoma cell line (Hartman et al., 2017).