The potential that GLP1-R agonists have for treating perinatal HIE has been further strengthened in two recent studies demonstrating: (1) that exendin-4 has significant therapeutic efficacy in the mouse model of neonatal HIE (Rocha-Ferreira et al., 2018), (2) and that liraglutide exerts neuroprotection via the PI3k/Akt pathway (Zeng et al., 2020). Here, GLP1R is linked to perinatal asphyxia.