Moreover, we observed an enhanced risk of colorectal cancer under allelic (Table 4, P = 0.021, OR = 1.20), homozygotic (P = 0.007, OR = 1.68), heterozygotic (Table 5, P = 0.041, OR = 1.46), and dominant (P = 0.016, OR = 1.54) conditions, implying the potential effect of the AG genotype of XPA rs1800975 on the risk of colorectal cancer. Here, XPA is linked to colorectal cancer.