Additionally, we detected a decreased lung cancer risk in cases under the GG vs. AA, AG vs. AA, AG + GG vs. AA models but an increased risk of colorectal cancer under the allelic, homozygotic, heterozygotic, dominant models, indicating the possible effect of the AG genotype of XPA rs1800975 on the susceptibility to colorectal cancer. The gene discussed is XPA; the disease is colorectal cancer.