CRNDE and central nervous system cancer: Although CRNDE was originally identified to be specifically high-expressed in CRC [17], overexpressed CRNDE was also observed in other cancers, such as glioma [18, 19], hepatocellular carcinoma (HCC) [20–24], lung cancer [25, 26], breast cancer (BC) [27], gastric cancer (GC) [28, 29], and renal cell carcinoma (RCC) [30, 31].