AKT1 and cancer: Specifically, diverse signaling pathways were found associated with CRNDE effect in cancers, such as the Wnt/β-catenin [20, 31–33], PI3K/AKT/mTOR [23, 26, 34], Ras/mitogen-activated protein kinase (MAPK) [35] and Notch1 signaling pathways [36].