To further examine the effect of HPRT1 on the dopaminergic neuron loss in 6-OHDA-induced PD mice, we injected lentiviral oe-NC or oe-HPRT1 into the 6-OHDA-induced PD mice, followed by detection of protein expression of HPRT1 in the substantia nigra tissues by western blot assay. This evidence concerns the gene HPRT1 and Parkinson disease.