The evidence provided by our study highlights the involvement of lncRNA H19 in the up-regulation of HPRT1 as well as the activation of the Wnt/β-catenin signaling pathway by binding to miR-301b-3p, which can rescue dopaminergic neuron loss in the 6-OHDA-induced PD model. Here, HPRT1 is linked to Parkinson disease.