Since miR-301b-3p expression is up-regulated in neurologic disorders [26], we selected miR-301b-3p as the research biomarker, to test the hypothesis that H19 might regulate HPRT1 expression by “sponging” miR-301b-3p, thus participating in the 6-OHDA-induced dopaminergic neuron loss. The gene discussed is HPRT1; the disease is nervous system disorder.