Zhang, Valdearcos and Kleinridders et al. blocked the inflammation-related IKKβ /NF-κB signaling pathway in neurons, microglia cells and the whole central nervous system, respectively, and found that all of them could significantly inhibit obesity induced by high-fat diet [39–41]. The gene discussed is NFKB1; the disease is obesity due to melanocortin 4 receptor deficiency.