Adult (young and aged) OPCs show higher expression than neonatal OPCs of some of the proteins associated with AD, PD, HD, and MS (e.g. TAU (67, 68), APOE (69), CRYAB (70, 71, 72, 73), TPPP (74), and SNCA (75, 76) (Fig. 8B). The gene discussed is MAPT; the disease is Alzheimer disease.