In addition, we also observed many of the hallmarks of ageing (47), including decreased levels of proteins involved in the maintenance of stem cell populations (e.g. SOX2 and SOX9) (Fig. 5B), chromatin remodelling (e.g. CHD7and ARID1) (Fig. 5C), cell cycle control (e.g. CDK1 and CDK2) (Fig. 5D) and in DNA repair (e.g. H2AFX or NUDT1) (Fig. 5E), as well as an increase in expression of proteins involved in cancer pathways (e.g. NRAS or KRAS) (Fig. 5F). The gene discussed is SOX2; the disease is cancer.