We also observed no statistically significant association after stratifying based on tumor expression of estrogen receptors, while we found a positive association between the 3rd quintile group of BDE-99 and PR- breast cancer risk (OR 3.13, 95%CI 1.03–9.54) and an inverse association between women in the 2nd quintile group of PBB-153 and PR+ breast cancer risk (OR 0.34, 95% CI 0.14–0.83) (Tables S3and S4). The gene discussed is ESR1; the disease is breast carcinoma.