BRCA1 and breast carcinoma: The main known risk factors for breast cancer include non-modifiable risk factors - such as age, early menarche, late menopause, family history of breast cancer, and genetic mutations (e.g. mutations in the BRCA1 and BRCA2 genes) - and modifiable risk factors - such as use of hormonal treatments, alcohol consumption, tobacco smoking, overweight, and lack of physical activity, [2].