In contrast, when the AD group was compared with the treatment groups, AD+40 (BDNF: P = .024, PSD95: P = .002, synaptophysin: P < .001), AD+EX (BDNF: P = .005, PSD95: P = .001; synaptophysin: P < .001), and AD+40+EX (P < .001 respectively) groups showed a significant increase. The gene discussed is BDNF; the disease is Alzheimer disease.