In contrast, when the AD group was compared with the treatment groups, significant differences were observed with the following treatment groups: AD+40 (Bax: P = .001, Bcl-2: P = .009, cytochrome C: P = .038, cleaved caspase-3P = .002), AD+EX (Bax: P = .001, Bcl-2: P = .002, cytochrome c: P = .013, cleaved caspase-3: P < .001), and AD+40+EX (P < .001 respectively). Here, CYCS is linked to Alzheimer disease.