CD80 and neoplasm: In addition, eosinophils are capable of regulating immunity, for instance, they can release major basic protein (MBP), a highly cationic protein to stimulate maturation of dendritic cells by increasing cell surface activation markers including MHC-II, CD80 and CD86, [43] which has the potential to overcome immune tolerance and induce anti-tumor immunity with the powerful antigen-presentation ability [44].