The close relation between TATE and better clinical outcome identified in this study possibly attribute to the following reasons: eosinophils in the TME can express same receptors and mediators such as granzyme A etc. as cytotoxic T lymphocytes (CTLs) and be directly involved in anti-tumor response, [41] and they can also secret several chemokines including CCL5, CXCL9 to promote anti-tumor immunity through attracting CD8+ T cells to the tumor site [42]. Here, CD8A is linked to neoplasm.