NRG1 and cancer: These sub-networks showed the interactions between paracrine factors and their receptors including TNF-TNFR (Figure 6(d)), NRG1-EGFR (ERBB) (Figure 6(e)), and WNT-FZD (Figure 6(e)) further indicated that paracrine factors TNF, NRG1, and WNT from infiltrated dendritic cells were involved in cancer pain.