The infiltrated dendritic cells in tumor microenvironment might not only synthesize hormones associated with neuropathic pain to directly control pain but also secret liquid factors such as TNF, PDGFA, WNT10A, and NRG1 to sensitize neurons so as to indirectly manage pain by up-regulated expression of pain-related genes via activating the transcription factors. The gene discussed is PDGFA; the disease is neoplasm.