More importantly, the paracrine factors derived from infiltrated dendritic cells such as tumor necrosis factor (TNF), platelet-derived growth factor-alpha (PDGFA), WNT10A, and neuregulin 1 (NRG1) were increased significantly, while scRNA-seq data from dorsal root ganglia (DRG) indicated that the increased paracrine factors might sensitize nociceptor sensory neurons in DRG by interacting with their receptors to aggravate neuropathic pain associated with cancers. The gene discussed is PDGFA; the disease is cancer.