It was reported that EV71 induces cell apoptosis through the mitochondrial pathway mediated by Caspase 9 [60,61], viral protein synthesis is essential for the induction of apoptosis in human glioblastoma SF268 cells [62], and EV71 3 C triggers apoptosis in SF268 cells [63]. This evidence concerns the gene CASP9 and glioblastoma.