LRRK2 and Parkinson disease: These include amino-terminal armadillo and ankyrin repeats, followed by 13 leucine rich repeat regions (LRR) and 7 WD40 repeats at the C-terminus.(Kumari and Tan, 2010; Gilsbach and Kortholt, 2014) To date, all mutations found to segregate with PD in families are clustered within the catalytic domains and have been found to alter the inherent biochemical properties of LRRK2.