PVR and neoplasm: Tumor resident cells showed increased expression of co-stimulatory molecules Alcam, Pvr, Tnfsf9 (4-1BBL), and Tnfsf4 (OX-40L) and inflammatory cytokines Il1β and Tnf. However, tumor macrophages, cDC1 cells, and migDCs were also more immunosuppressive, displaying higher levels of Arg1 (arginase-1), Lgals9 (galectin-9), Cd247 (Pdl1), and Pdcd1lg2 (Pdl2), respectively (Figure 2D).