Elevated C3 and C3a have been detected at the primary tumor and in the serum of several solid cancers and are associated with poor prognosis in ovarian cancer (Canales et al., 2014, Chen et al., 2013, Cho et al., 2014, Gast et al., 2009, Habermann et al., 2006). This evidence concerns the gene C3 and ovarian carcinoma.