Moreover, it was found that miR-137 and miR-7847 were less packaged in exosomes after WSSV challenge, resulting in the activation of AIF, while AIF could translocate to nucleus to induce DNA fragmentation or disintegrate the HSP70-Bax complex and freeing Bax to mitochondria, which eventually caused apoptosis and suppressed viral infection of the recipient hemocytes. Here, BAX is linked to viral infectious disease.