Serum PlGF and another biomarker serum pregnancy-associated plasma protein A (PAPP-A) have been incorporated into the algorithm of the International Federation of Gynecology and Obstetrics (FIGO) for pre-eclampsia screening in first-trimester with detection rates of preterm and term preeclampsia between 75%-77% and 47%-54% at false-positive rate of 10% [4]. The gene discussed is PGF; the disease is preeclampsia.