Here, we investigated whether SNPs located in eleven genes: CCDC122/LACC1, IFNG, IL6, IL10, IL23R, LRRK2, NOD2, PACRG/PRKN, TLR1, TNF and TYK2 are associated to leprosy susceptibility in a population in the North of Brazil. The gene discussed is NOD2; the disease is leprosy.