Based on these assumptions, the associations between metabolic components and inflammatory markers (e. g., high-sensitivity C-reactive protein [hs-CRP], interleukin-6 [IL]-6) [6,9–11], and markers of endothelial dysfunction (e. g., intercellular adhesion molecule [ICAM-1] and vascular cell adhesion molecule [VCAM-1]) [6,11,12] have been evaluated. The gene discussed is ICAM1; the disease is endothelial dysfunction.