NDRG2 can also activate glycogen synthase kinase 3β (GSK-3β), impacting β-catenin signaling[103] and potentially contributing to cardiomyopathy establishment as the GSK3 family has been implicated in the regulation of cardiac remodeling downstream of the PI3K–Akt pathway[104]. The gene discussed is GSK3B; the disease is cardiomyopathy.