PGLYRP1 and colitis: The AIM2 inflammasome was described to regulate intestinal homeostasis through the IL-18/IL-22/STAT3 pathway.79 Mammalian peptidoglycan recognition proteins (PGRPs) protect the host from colitis by promoting balanced microbiota configuration and by preventing production of IFNγ by NK cells in response to injury.80 These protective effects are in part achieved synergistically with NOD2.81 IPAF is an important member of the NOD‐LRR family of proteins.