Of interest, Ecuadorian people with the Laron syndrome, a rare form of short stature with a mutation in the growth hormone (GH) receptor and extremely low IGF-1 serum levels have very low susceptibility to cancer40, stressing a central role for the IGF-IGFBP axis in fueling cell proliferation and opposing apoptosis in cancer cells. This evidence concerns the gene GH1 and Laron syndrome.