CNR1 and major depressive disorder: By linear regression, the expression of the CNR1 gene is marginally decreased in the DLPFC of the patients with schizophrenia (p = 1.61E−02, FDR = 4.83E−02), but not in patients with bipolar disorder (p = 5.19E−02) or MDD (p = 0.81) (Supplementary Fig. 3).