To further characterize the molecular correlates underlying clinical associations of the ECS with psychosis in general and schizophrenia in particular, we measured the mRNA expression of CNR1 across the human life span in the prefrontal cortex (PFC) and hippocampus and, based upon the Caspi study (2005)6, established expression profiles of the CNR1 transcripts based on age and COMT genotype. The gene discussed is COMT; the disease is psychotic disorder.