In DLPFC, the expression of CNR1 at the gene level (Fig. 2) is significantly decreased in patients with schizophrenia (p = 3.31E−04, FDR = 9.92E−04) and patients with MDD (p = 1.67E−04, FDR = 7.50E−04) compared with non-psychiatric controls, but not in patients with bipolar disorder (p = 5.49E−02). This evidence concerns the gene CNR1 and major depressive disorder.