Hepatitis B virus and hepatitis C virus (HBV and HCV, respectively) enhance the phosphorylation of Drp1 (Ser616), and promote its translocation to mitochondria.25,26 Mitochondrial fragmentation is closely related to the regulation of Drp1 by EBV-LMP2A, guiding cell migration and epithelial–mesenchymal transition in gastric cancer and breast cancer cells.23 Our data showed that EBV-LMP1 differentially regulates Drp1 phosphorylation at Ser616 and Ser637, significantly increasing mitochondrial fission. The gene discussed is DNM1L; the disease is breast cancer.