Accumulating evidence shows that Drp1-induced mitochondrial fission is associated with a shift in pro-glycolytic activity.39 Moreover, BRAF-V600E-driven melanoma cells have high levels of mitochondrial fission, which enhances glycolytic metabolism.10 Consistent with these findings, our results showed that the phosphorylation of Drp1 (Ser616 or Ser637) was indispensable for the enhanced glycolytic metabolism regulated by LMP1. This evidence concerns the gene DNM1L and melanoma.