Recently, studies revealed that suppression of the activity of Drp1 results in the release of cytochrome c, which leads to apoptosis.40 Other studies indicated that inactivation of Drp1 led to programmed necrotic cell death.41 TNF-α and Mdivi-1 reduce mitochondrial fission and increase necroptosis.42 Mdivi-1 induced cell death in vitro, suggesting that Mdivi-1 inhibited mitochondrial fission and suppressed cancer cell survival.7,37 Herein, we noted that EBV-LMP1 exerted a strong influence on mitochondrial function by promoting mitochondrial division. Here, TNF is linked to cancer.