NLRP6 and colitis: with autoimmune diseases, insulin resistance and diabetes, and gut inflammation.22,26,27 Specifically, an overabundance of Prevotella copri was noted in new-onset rheumatoid arthritis (NORA) patients22 and also in patients with systemic autoimmunity associated with RA, but without clinical symptoms yet.28 In mouse models, an altered gut microbiota dominated by a member of the genus Prevotella was discovered in NLRP6-deficient mice and was associated with higher susceptibility to chemically-induced colitis.21 Interestingly, Prevotella spp.