Over-activation and hypersensitivity to interferon (IFN) signaling, resulting from increased expression of IFN-related genes located on Hsa21 (including IFNAR1, IFNAR2, IFNGR2 and IL10RB) outside of the DSCR region, has been observed in multiple cell types in individuals with DS [110]. This evidence concerns the gene IFNA1 and Dravet syndrome.