Upon topical application of imiquimod (IMQ), a synthetic Toll-like receptor 7 (TLR7) ligand, on the ear skin11,13, Cd103−/− mice displayed a more prominent psoriasiform dermatitis, such as thickening and scaling than WT mice (Fig. 2a,b). The gene discussed is ITGAE; the disease is Psoriasiform dermatitis.