In this report, we show that infusion of angiotensin II at a dose of 600 ng/kg/min in combination with 1% NaCl in the drinking water in male C57BL/6 N mice constitutes a model of hypertension-associated HFpEF characterized by cardiac concentric hypertrophy, capillary rarefaction, increased interstitial and perivascular fibrosis, oxidative stress, pronounced cardiac dysfunction, and pulmonary congestion. Here, AGT is linked to Hypertension.