Indeed, mutations in two exocyst subunits, exocyst complex component 84 (EXO84; also known as EXOC8) and SEC8 (also known as EXOC4), have been found in the ciliopathies Joubert syndrome and Meckel–Gruber syndrome (Dixon-Salazar et al., 2012; Shaheen et al., 2013a,b). The gene discussed is EXOC4; the disease is Joubert syndrome.