SH3TC2 and Charcot-Marie-Tooth disease type 4: For example, recessive demyelinating forms of CMT (CMT4) result from mutation of the endocytic recycling protein SH3 domain and tetratricopeptide repeats 2 (SH3TC2) (Senderek et al., 2003), as well as the myotubularins and FIG4, which influence traffic by acting upon endosomal phosphoinositides (Azzedine et al., 2003; Bolino et al., 2000; Nakhro et al., 2013; Zhang et al., 2008).