Chediak–Higashi syndrome, which manifests as albinism, excessive bleeding and immunodeficiency, is caused by mutations in lysosomal trafficking regulator (LYST) (Karim et al., 2002), which appears to function in endolysosomal trafficking (Gil-Krzewska et al., 2016). This evidence concerns the gene LYST and Chédiak-Higashi syndrome.