Genetic association studies link variants or altered expression levels of the clathrin-mediated endocytosis components phosphatidylinositol-binding clathrin assembly protein (PICALM) (Harold et al., 2009; Jun et al., 2010), bridging integrator 1 (BIN1)/amphiphysin 2 (Hu et al., 2011; Seshadri et al., 2010), cortactin-CD2-associated protein (CD2AP) (Hollingworth et al., 2011; Naj et al., 2011) and synaptojanin (McMahon and Boucrot, 2011; Miranda et al., 2018), with the risk of acquiring Alzheimer's disease (AD). The gene discussed is PICALM; the disease is Alzheimer disease.