EPAS1 and metabolic dysfunction-associated steatohepatitis: More interestingly, we observed that histological features of NASH significantly ameliorated in Vhlf/fHif2αf/f‐deficient mice along with a marked decrease of both mRNA and protein hepatic CD36 levels, supporting our assumption that HIF2α may contribute to NAFLD onset by upregulating CD36 expression and function in hepatocytes.