The results of luciferase activity assay indicated that after co-transfection of a gene plasmid containing the SNHG12 wild -type sequence with miR-320b, luciferase relative activity significantly decreased, which suggested that the expression of SNHG12 in pancreatic cancer cells would be suppressed through the direct binding between miR-320b and WT SNHG12 (Figure 4B). Here, SNHG12 is linked to familial pancreatic carcinoma.