TLR4 and Parkinson disease: In the western blotting analysis, the expressions of TLR4, MyD88, p-IкBα, p-NF-кB, TXNIP, NLRP3, ASC and cleaved Caspase-1 were significantly increased in MPTP-induced PD mice, while Sal significantly reversed these changes (Figures 4A, 5A).