We prepared homogenates from biobanked samples used in the reported study and reproduced the results using RIFS (Fig 7M–P), where pheochromocytoma homogenates showed increased ETC activity, mitochondrial mass, UCP1, and ETC protein levels, as described when browning occurs (Abdullahi & Jeschke, 2016; Cui & Chen, 2016; Winn et al, 2019). The gene discussed is UCP1; the disease is hereditary pheochromocytoma-paraganglioma.