AKT1 and malignant colon neoplasm: Activation of PI3K‐Akt pathway could take part in protecting gastric mucosal epithelium against damage.20 In cancer patients, multiple components of the PI3K‐Akt signaling pathway were amplified, mutated, and translocated more frequently compared with other pathways, resulting in pathway activation.21 cGMP‐PKG signaling pathway involved in the treatment and prevention of numerous cancers, including cervical cancer, colon cancer, and breast cancer.22, 23, 24 In the GSEA analysis, we also found many immune‐related biological processes taking part in the molecular mechanism.