On the hepatocyte basolateral side, FXR activation leads to increased expression of OSTα/β, MRP3, and MRP4 which in the setting of cholestasis can efflux bile salts from the basolateral surface of the hepatocyte to reduce intracellular bile acid concentrations and therefore mitigate the toxic effects of bile acids to the cell (46, 63). This evidence concerns the gene NR1H4 and cholestasis.