Although the pathophysiological roles of s-CD95L remain to be elucidated, it accumulates in the bloodstream of patients suffering from a variety of diseases, including certain cancers such as NK cell lymphomas (Tanaka et al., 1996), ovarian cancers (De La Motte Rouge et al., 2019), and triple-negative breast cancer (TNBC) (Malleter et al., 2013). The gene discussed is FASLG; the disease is cancer.