Our previous study (Xu et al., 2014), as well as other researchers’ study (Ni et al., 2014), have found that the transactivation activity of FOXO3 was able to promote cell cycle, cell proliferation, and EMT by reducing the levels of p21Cip1 and p27Kip1, and increases expression of CCND1 and Snail in RCC cells. The gene discussed is CDKN1A; the disease is renal cell carcinoma.