Liu et al. (2017) reported that SP1 could bind to the promoter region of SNHG14 to unregulate its expression in clear cell renal cell carcinoma (ccRCC). Enhanced expression of lncRNA SNHG14 promoted cell migration and invasion by promoting N-WASP protein level. Wu et al. (2016) found that SP1 was a direct target of miR-429, which was able to inhibit cell proliferation, migration, and invasion. The gene discussed is WASL; the disease is nonpapillary renal cell carcinoma.