Approximately 20% of genome-wide MS susceptibility variants fall within and/or proximal to NF-κB signaling genes, including NFKB1 or p105/p50 and TNFRSF1A (TNFR1), which cause decreased expression of the negative regulators of NF-κB (De Jager et al., 2009; Housley et al., 2015). The gene discussed is NFKB1; the disease is myeloid sarcoma.