As shown in a GWAS noise reduction (GWAS-NR), an approach to detect novel associations beyond those detected by traditional GWAS, variants regulating the activation and proliferation of immune effector cells, comprising key regulators of NF-κB signaling, are involved in the genetic susceptibility to MS (Hussman et al., 2016). This evidence concerns the gene NFKB1 and myeloid sarcoma.