Our group has developed the folic acid-conjugated PEGylated PLGA nanoparticles co-encapsulated with CdSe/ZnS quantum dots, doxorubicin and Fe3O4 nanoparticles followed by the adsorption of vascular endothelial growth factor (VEGF)-targeted small hairpin RNA (abbreviated as LDM-PLGA/PPF/VEGF shRNA) for tumor targeted drug delivery and cancer imaging (Shen et al., 2017). The gene discussed is VEGFA; the disease is cancer.