RPS16 and cytomegalovirus infection: During HCMV infection, pUL34 acts as transcriptional repressor for viral genes such as US3 and US9. Additionally, pUL34 binds the oriLyt region (LaPierre and Biegalke, 2001; Liu and Biegalke, 2013) and enhances the efficiency of oriLyt-dependent DNA replication of plasmids (Slayton et al., 2018).