In the in vitro experiments, we found that primary glioma stem cell spheres (DP3321 and DP7857) had extremely high tube formation capacities and that inhibiting BMPER, CXCL10, or HOXA9 expression significantly reduced the angiogenic capacities of the tumor cells, indicating that these three genes can promote tumor-derived neovascularization in primary high-grade gliomas obviously. This evidence concerns the gene BMPER and central nervous system cancer.