We also found that the DSC-MRI and DCR-MRI scanning parameters rCBV, rCBF, Vp, and Ktrans could be used as imaging biomarkers to non-invasively predict BMPER, CXCL10, and HOXA9 expression in tumor tissue, which provides an effective means of diagnosing, treating, and monitoring primary high-grade glioma. Here, CXCL10 is linked to central nervous system cancer.