Our risk signature is comprised of seven genes, including PINK1, BID, VAMP3, BAG1, ST13, PIK3R4, and CASP4. Our results found PINK1, VAMP3, BAG1, ST13, and PIK3R4 as protect factors and BID, CASP4 as risk factors for ccRCC. This evidence concerns the gene VAMP3 and nonpapillary renal cell carcinoma.