Our risk signature is comprised of seven genes, including PINK1, BID, VAMP3, BAG1, ST13, PIK3R4, and CASP4. Our results found PINK1, VAMP3, BAG1, ST13, and PIK3R4 as protect factors and BID, CASP4 as risk factors for ccRCC. The gene discussed is CASP4; the disease is nonpapillary renal cell carcinoma.