SNAI2 and leukemia: Few reports indicate that EMT-transcription factors (TFs), including Twist-1 and Slug, are implicated in hematopoietic stem cell self-renewal by interacting with stemness signaling key factors c-Myc and c-Kit (30, 31) while Slug up-regulation promotes leukemogenesis and confers resistance to apoptosis in leukemia cells (32).