In chronic myelogenous leukemia (CML) cells, CXCR4 activates PI3K/AKT signaling pathway and promotes the translocation of NF-κB complexes into nucleus thereby decreasing the expression of pro-apoptotic proteins (23, 24). The gene discussed is NFKB1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.