Our results provide further evidence regarding NF-κB's involvement in EMT regulation also in the hematological malignancies since, in K562shFtH cells, p65 nuclear translocation is accompanied by the over expression of the two key EMT-TF Snail and Slug and of the major mesenchymal marker Vimentin in association with the break-down of the epithelial marker E-cadherin. Here, SNAI2 is linked to hematologic disorder.